Masahiko Morita Selected Research

4- (3- isopropyl- 5- (6- phenyl- 3- pyridyl)- 4H- 1,2,4- triazol- 4- yl)- 2,1,3- benzoxadiazole

6/2012

A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.

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Masahiko Morita Research Topics

Disease

3	Alzheimer Disease (Alzheimer's Disease) 06/2012 - 10/2009
2	Cognitive Dysfunction 01/2023 - 06/2012
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 07/2013
2	Atrophy 09/2017 - 01/2015
2	Erectile Dysfunction 06/2014 - 10/2013
2	Brain Ischemia (Cerebral Ischemia) 07/2013 - 01/2011
1	Diabetic Retinopathy (Retinopathy, Diabetic) 03/2021
1	Diabetes Mellitus 03/2021
1	Sarcopenia 01/2020
1	Gyrate Atrophy 01/2015
1	Cataract (Cataracts) 01/2015
1	Ganglion Cysts (Ganglion) 01/2015
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2015
1	Cold Hypersensitivity 10/2014
1	Ischemia 07/2013
1	Memory Disorders (Memory Loss) 07/2013
1	Mental Disorders (Mental Disorder) 06/2012
1	Schizophrenia (Dementia Praecox) 06/2012
1	Dementia (Dementias) 01/2011
1	Stroke (Strokes) 01/2011
1	Illusions (Auditory Illusions) 03/2010

Drug/Important Bio-Agent (IBA)

5	CitrullineIBA 03/2021 - 07/2013
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 07/2013
1	Biomarkers (Surrogate Marker)IBA 01/2023
1	Glutathione (Reduced Glutathione)IBA 09/2017
1	OrnithineIBA 01/2015
1	EnzymesIBA 01/2015
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 10/2014
1	Arginine (L-Arginine)FDA Link 07/2013
1	serum P-component (CIt)IBA 07/2013
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 06/2012
1	4- (3- isopropyl- 5- (6- phenyl- 3- pyridyl)- 4H- 1,2,4- triazol- 4- yl)- 2,1,3- benzoxadiazoleIBA 06/2012
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 06/2012
1	N-Methylaspartate (NMDA)IBA 06/2012
1	Neuroprotective AgentsIBA 01/2011
1	Cytidine Diphosphate Choline (Citicoline)IBA 01/2011
1	Donepezil (Aricept)FDA LinkGeneric 01/2011
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/2009

Therapy/Procedure

1	Oral Administration 07/2013
1	Telescopes 03/2010